Negative regulation of post-translational protein modification

Across TCGA patient cohorts, RNA activity of the Negative regulation of post-translational protein modification pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHH1, LIMK1, and IFI16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of post-translational protein modification activity versus PLEKHH1 in LSCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLEKHH1 →	-0.460	-0.101	.002	<.001	3	5
CCRCC	LIMK1 →	+0.757	+0.233	<.001	<.001	3	5
UCEC	IFI16 →	+0.685	+0.139	<.001	.004	3	4
GBM	ADAMTS17 →	-0.539	-0.105	<.001	<.001	3	4
LSCC	CTSC →	+0.610	+0.112	<.001	.001	3	4
LSCC	PAIP2B →	-0.463	-0.077	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901874 vs PLEKHH1 — LSCC

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