Negative regulation of post-translational protein modification

Across TCGA cell cohorts, RNA activity of the Negative regulation of post-translational protein modification pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RARS1, KCNAB2, and SYNPO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RARS1 grouped by Negative regulation of post-translational protein modification-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RARS1 →	-0.358	-0.081	.006	.001	3	5
LIVER	KCNAB2 →	+0.237	+0.071	.006	.007	3	5
OESOPHAGUS	SYNPO →	+0.133	+0.069	.002	.006	3	4
LIVER	ARHGEF2 →	-0.353	-0.106	.001	.003	3	4
LIVER	SSR1 →	+0.495	+0.092	.004	.003	3	4
LIVER	SSTR4 →	+0.248	+0.101	.009	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RARS1 by Negative regulation of post-translational protein modification activity — LIVER

Explore this box plot interactively →