Negative regulation of post-translational protein modification

Across TCGA cell cohorts, RNA activity of the Negative regulation of post-translational protein modification pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBA, P3H1, and DDOST, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of post-translational protein modification activity versus INHBA in BONE (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	INHBA →	+4.083	+0.189	<.001	<.001	3	6
BREAST	P3H1 →	+2.163	+0.361	<.001	<.001	3	6
BONE	DDOST →	+0.820	+0.189	<.001	<.001	3	6
BLOOD_Lymphoma	MYB →	-1.904	-0.178	.002	<.001	3	6
BREAST	DKK3 →	+3.490	+0.397	<.001	<.001	3	6
BREAST	BMP1 →	+1.782	+0.314	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901874 vs INHBA — BONE

Explore this scatter interactively →