Regulation of post-translational protein modification

Across TCGA patient cohorts, RNA activity of the Regulation of post-translational protein modification pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGSM3, MLYCD, and SMARCB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of post-translational protein modification activity versus SGSM3 in LUAD (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SGSM3 →	-0.438	-0.027	.005	.002	3	6
CCRCC	MLYCD →	-0.395	-0.022	<.001	<.001	3	6
LSCC	SMARCB1 →	+0.195	+0.027	.003	.001	3	6
LUAD	BCAS1 →	-1.074	-0.027	.002	.001	3	6
BRCA	HAPLN3 →	+0.577	+0.023	<.001	.003	3	5
BRCA	MCEE →	-0.348	-0.019	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901873 vs SGSM3 — LUAD

Explore this scatter interactively →