Regulation of post-translational protein modification

Across TCGA cell cohorts, RNA activity of the Regulation of post-translational protein modification pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UTRN, DFFA, and SAFB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of post-translational protein modification activity versus UTRN in PANCREAS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UTRN →	+1.292	+0.127	.002	.006	3	5
PANCREAS	DFFA →	+0.915	+0.158	.001	.003	3	5
BONE	SAFB →	+0.815	+0.282	.006	.002	3	5
BLOOD_Leukemia	PAQR3 →	+1.173	+0.154	<.001	<.001	3	5
BREAST	FGD1 →	+1.184	+0.134	.001	.007	3	5
BLOOD_Leukemia	XRN1 →	+0.559	+0.089	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901873 vs UTRN — PANCREAS

Explore this scatter interactively →