Negative regulation of muscle tissue development

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC39A6, CEP170, and VCAN-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle tissue development activity versus SLC39A6 in LUAD (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC39A6 →	+0.351	+0.151	.002	.006	3	3
LUAD	CEP170 →	+0.353	+0.172	.001	.004	3	3
HNSC	VCAN-AS1 →	+1.172	+0.719	.002	.002	2	4
GBM	CTSL →	+0.640	+0.644	.001	.001	3	3
GBM	FTH1P5 →	+0.252	+0.668	<.001	.001	2	4
GBM	LINC01003 →	-0.388	-0.586	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901862 vs SLC39A6 — LUAD

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