Negative regulation of muscle tissue development

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGL1, PNPLA3, and MEIG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGL1 grouped by Negative regulation of muscle tissue development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RGL1 →	-1.374	-0.769	.004	.008	3	4
CNS	PNPLA3 →	-1.127	-0.622	<.001	.005	3	4
CNS	MEIG1 →	+0.414	+0.862	<.001	.002	3	4
LARGE_INTESTINE	GNB3 →	+0.794	+0.987	.006	.001	3	3
LUNG_NSCLC_LUSC	PACS2 →	+0.640	+1.453	.002	<.001	3	3
SOFT_TISSUE	CBLB →	-2.095	-1.244	<.001	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGL1 by Negative regulation of muscle tissue development activity — SOFT_TISSUE

Explore this box plot interactively →