Negative regulation of muscle tissue development

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBNDD2, FIS1, and MRPS33, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle tissue development activity versus DBNDD2 in LUNG_SCLC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DBNDD2 →	+1.583	+1.716	.009	.001	3	4
LUNG_SCLC	FIS1 →	+0.989	+1.760	.004	<.001	3	3
OESOPHAGUS	MRPS33 →	+0.761	+0.430	<.001	.009	3	3
BLOOD_Lymphoma	SPTBN1 →	-3.082	-0.154	.006	.005	2	4
BLOOD_Lymphoma	CISD3 →	+1.230	+0.258	<.001	.004	3	3
BLOOD_Lymphoma	LIMA1 →	+2.547	+0.290	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901862 vs DBNDD2 — LUNG_SCLC

Explore this scatter interactively →