Regulation of mitochondrial DNA metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial DNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are N4BP1, LIG3, and RASSF5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial DNA metabolic process activity versus N4BP1 in CCRCC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	N4BP1 →	-0.167	-0.067	<.001	<.001	3	6
LSCC	LIG3 →	+0.576	+0.081	<.001	<.001	3	6
LSCC	RASSF5 →	-0.389	-0.075	<.001	<.001	3	6
COAD	SFXN3 →	-0.303	-0.033	<.001	.001	3	5
HNSC	ZNF318_S91 →	+0.596	+0.086	<.001	<.001	3	5
LSCC	GINS3 →	+0.711	+0.077	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901858 vs N4BP1 — CCRCC

Explore this scatter interactively →