Regulation of mitochondrial DNA metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial DNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDHB, DNAJB6, and MDH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial DNA metabolic process activity versus PDHB in BLOOD_Myeloma (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PDHB →	-0.927	-0.119	.003	.006	3	5
SOFT_TISSUE	DNAJB6 →	+1.192	+0.131	.003	.006	3	4
OESOPHAGUS	MDH1 →	-0.834	-0.086	.002	.002	3	4
BLOOD_Myeloma	DOCK4 →	+1.575	+0.106	<.001	.001	2	5
OESOPHAGUS	ZNF620 →	-1.004	-0.091	.005	.007	3	4
LARGE_INTESTINE	COQ2 →	-0.865	-0.077	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901858 vs PDHB — BLOOD_Myeloma

Explore this scatter interactively →