Positive regulation of cellular respiration

Across TCGA patient cohorts, RNA activity of the Positive regulation of cellular respiration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PMPCA, UQCRH, and CYC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular respiration activity versus PMPCA in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PMPCA →	+0.306	+0.042	<.001	.001	3	6
GBM	UQCRH →	+0.360	+0.052	.005	.004	3	6
GBM	CYC1 →	+0.269	+0.067	<.001	<.001	3	6
PDAC	UQCR10 →	+0.595	+0.060	<.001	<.001	3	5
BRCA	DNAJC19 →	+0.329	+0.032	.003	.005	3	5
BRCA	FASTKD5 →	+0.298	+0.036	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901857 vs PMPCA — BRCA

Explore this scatter interactively →