Positive regulation of cellular respiration

Across TCGA patient cohorts, RNA activity of the Positive regulation of cellular respiration pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-758P, RN7SL262P, and C1QTNF2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular respiration activity versus RNU6-758P in OV (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNU6-758P →	-0.224	-0.167	.006	.005	3	3
CCRCC	RN7SL262P →	+0.398	+0.463	.001	.001	3	3
LSCC	C1QTNF2 →	-0.321	-0.722	.004	.003	3	3
BRCA	GABARAP →	-0.206	-0.732	.005	<.001	3	3
BRCA	PPIAP19 →	-1.252	-0.765	.004	.002	3	3
OV	GALNT3 →	-0.853	-0.122	.002	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901857 vs RNU6-758P — OV

Explore this scatter interactively →