Positive regulation of cellular respiration

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular respiration pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF624, PDE4D, and LPAR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF624 grouped by Positive regulation of cellular respiration-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF624 →	+0.493	+0.191	.002	.003	3	3
LUNG_NSCLC_LUSC	PDE4D →	-2.410	-0.139	.004	<.001	3	3
LUNG_NSCLC_LUSC	LPAR2 →	+1.808	+0.120	<.001	.005	3	3
SOFT_TISSUE	SAMM50 →	-0.429	-0.121	.007	.009	3	3
CNS	IFT22 →	-0.892	-0.707	<.001	.004	3	3
KIDNEY	ERLIN2 →	-0.821	-0.263	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF624 by Positive regulation of cellular respiration activity — STOMACH

Explore this box plot interactively →