Positive regulation of cellular respiration

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular respiration pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDRT1, UBA2, and HSPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular respiration activity versus CDRT1 in OVARY (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CDRT1 →	-1.197	-0.238	.007	.008	3	6
UPPER_AERODIGESTIVE_TRACT	UBA2 →	+0.738	+0.246	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	HSPD1 →	+1.427	+0.309	.003	.001	3	6
BLOOD_Lymphoma	UNC13D →	-2.118	-0.108	.006	<.001	2	6
URINARY_TRACT	LYPD3 →	-4.784	-0.291	<.001	.005	2	6
OESOPHAGUS	COL17A1 →	-2.976	-0.132	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901857 vs CDRT1 — OVARY

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