Negative regulation of cellular respiration

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular respiration pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIF, QARS1, and CUEDC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular respiration activity versus PPIF in BREAST (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PPIF →	+0.899	+0.152	.002	.007	3	10
SKIN	QARS1 →	+0.837	+0.302	<.001	.004	3	5
BREAST	CUEDC2 →	+0.583	+0.185	.008	.008	3	4
BREAST	DNAJC27 →	-0.428	-0.184	.001	.005	3	4
BREAST	ZNF260 →	-0.801	-0.190	.003	.002	3	4
BREAST	RPAP3 →	-0.469	-0.242	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901856 vs PPIF — BREAST

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