Regulation of cell communication by electrical coupling involved in cardiac conduction

Across TCGA patient cohorts, RNA activity of the Regulation of cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, EBF2, and LHFPL6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell communication by electrical coupling involved in cardiac conduction activity versus MSRB3 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MSRB3 →	+1.237	+0.361	<.001	.003	3	7
BRCA	EBF2 →	+0.823	+0.449	<.001	.007	3	7
BRCA	LHFPL6 →	+1.511	+0.594	<.001	.001	2	7
LSCC	PTGIR →	+0.426	+0.668	<.001	.004	3	6
BRCA	IGFBP7 →	+1.047	+0.652	<.001	.001	3	6
BRCA	JAM2 →	+1.048	+0.552	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901844 vs MSRB3 — BRCA

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