Regulation of cell communication by electrical coupling involved in cardiac conduction

Across TCGA cell cohorts, RNA activity of the Regulation of cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELENOM, ACTR10, and ZNF189, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SELENOM grouped by Regulation of cell communication by electrical coupling involved in cardiac conduction-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SELENOM →	-3.123	-1.639	.008	<.001	3	5
OVARY	ACTR10 →	-0.540	-0.782	.004	.005	3	4
BLOOD_Myeloma	ZNF189 →	+0.840	+1.699	.006	.001	3	4
BONE	INKA1 →	+2.147	+1.537	.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	LARS1 →	+1.501	+1.198	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	TENT2 →	+1.298	+1.450	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SELENOM by Regulation of cell communication by electrical coupling involved in cardiac conduction activity — BONE

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