Regulation of cell communication by electrical coupling involved in cardiac conduction

Across TCGA cell cohorts, RNA activity of the Regulation of cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FFAR1, CEBPA, and RAB17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FFAR1 grouped by Regulation of cell communication by electrical coupling involved in cardiac conduction-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FFAR1 →	-0.273	-0.199	.002	.001	3	5
BLOOD_Leukemia	CEBPA →	-0.382	-0.135	<.001	.002	3	5
SOFT_TISSUE	RAB17 →	-0.380	-0.226	<.001	<.001	3	5
SKIN	COPS6 →	-0.283	-0.137	<.001	.002	3	5
PANCREAS	PCSK5 →	-0.168	-0.141	.002	.003	3	4
BLOOD_Leukemia	RNF128 →	+0.286	+0.178	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FFAR1 by Regulation of cell communication by electrical coupling involved in cardiac conduction activity — BLOOD_Leukemia

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