Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, SMARCA5, and TPX2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I activity versus RFC2 in GBM (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC2 →	+0.427	+0.061	<.001	<.001	3	8
GBM	SMARCA5 →	+0.361	+0.055	<.001	<.001	3	8
LUAD	TPX2 →	+0.856	+0.051	<.001	.001	3	8
LSCC	UNG_S23 →	+0.962	+0.067	<.001	<.001	3	8
HNSC	UTP4 →	+0.323	+0.081	<.001	<.001	3	8
BRCA	CHAF1A →	+0.589	+0.061	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901838 vs RFC2 — GBM

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