Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, CENPH, and DEPDC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I activity versus TTK in PDAC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TTK →	+0.772	+0.523	<.001	<.001	3	8
UCEC	CENPH →	+0.690	+0.480	.001	<.001	3	8
GBM	DEPDC1 →	+0.971	+0.498	<.001	<.001	3	8
LUAD	MYBL2 →	+1.094	+0.378	<.001	<.001	3	7
LUAD	FAM83D →	+0.781	+0.320	<.001	.001	3	7
LUAD	FOXM1 →	+0.867	+0.386	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901838 vs TTK — PDAC

Explore this scatter interactively →