Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UHRF2, PGAM5, and MRPS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UHRF2 grouped by Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UHRF2 →	-0.804	-0.257	.005	.002	3	4
PANCREAS	PGAM5 →	+0.716	+0.235	.003	.003	3	4
BLOOD_Myeloma	MRPS2 →	+0.836	+0.207	.003	.001	3	4
BLOOD_Myeloma	MMAB →	+1.325	+0.234	<.001	<.001	3	4
LARGE_INTESTINE	BCAN →	-0.267	-0.220	.005	.003	3	4
SKIN	ZDHHC11B →	+1.217	+0.121	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UHRF2 by Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I activity — BREAST

Explore this box plot interactively →