Regulation of transcription of nucleolar large rRNA by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Regulation of transcription of nucleolar large rRNA by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNB2, ORC6, and PAICS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription of nucleolar large rRNA by RNA polymerase I activity versus CCNB2 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCNB2 →	+0.884	+0.327	.003	<.001	3	8
GBM	ORC6 →	+0.881	+0.392	<.001	<.001	3	8
LUAD	PAICS →	+0.511	+0.300	.001	.001	3	7
GBM	RACGAP1 →	+0.681	+0.300	<.001	.001	3	7
GBM	POC1A →	+0.625	+0.277	<.001	<.001	3	7
BRCA	TRIP13 →	+0.842	+0.246	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901836 vs CCNB2 — BRCA

Explore this scatter interactively →