Regulation of transcription of nucleolar large rRNA by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Regulation of transcription of nucleolar large rRNA by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COLGALT2, LRP6, and DNAJB5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COLGALT2 grouped by Regulation of transcription of nucleolar large rRNA by RNA polymerase I-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	COLGALT2 →	-1.807	-0.272	<.001	<.001	3	6
CNS	LRP6 →	-0.596	-0.247	.002	.003	3	5
OESOPHAGUS	DNAJB5 →	-1.461	-0.221	.006	.002	3	5
LUNG_NSCLC_LUSC	ST3GAL3 →	-1.882	-0.287	<.001	<.001	3	5
BLOOD_Lymphoma	GALC →	-2.202	-0.580	.002	.001	3	4
CNS	BVES →	-1.490	-0.227	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COLGALT2 by Regulation of transcription of nucleolar large rRNA by RNA polymerase I activity — LUNG_NSCLC_LUSC

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