Regulation of transcription of nucleolar large rRNA by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Regulation of transcription of nucleolar large rRNA by RNA polymerase I pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEBPZ, LBH, and PDIA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEBPZ grouped by Regulation of transcription of nucleolar large rRNA by RNA polymerase I-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CEBPZ →	-0.195	-0.065	<.001	.005	3	5
SOFT_TISSUE	LBH →	+0.430	+0.162	.006	.005	3	5
LARGE_INTESTINE	PDIA3 →	-0.181	-0.074	.001	.004	3	4
LARGE_INTESTINE	POLR3C →	+0.267	+0.099	.003	.005	3	4
BREAST	NAT8B →	+0.134	+0.097	.003	.004	3	4
BLOOD_Leukemia	BRWD1 →	+0.196	+0.072	.004	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEBPZ by Regulation of transcription of nucleolar large rRNA by RNA polymerase I activity — CNS

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