Regulation of transcription of nucleolar large rRNA by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Regulation of transcription of nucleolar large rRNA by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM25, SMARCC1, and RPS27L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription of nucleolar large rRNA by RNA polymerase I activity versus TMEM25 in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TMEM25 →	+2.300	+0.267	<.001	.001	3	6
BLOOD_Leukemia	SMARCC1 →	+0.558	+0.218	.002	<.001	3	6
OVARY	RPS27L →	-1.639	-0.336	<.001	<.001	3	6
LUNG_NSCLC_LUSC	CD63 →	-1.552	-0.374	.001	.001	3	6
LUNG_NSCLC_LUSC	BLVRB →	-1.901	-0.278	.002	.003	3	6
OVARY	MPG →	-0.663	-0.265	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901836 vs TMEM25 — LIVER

Explore this scatter interactively →