Positive regulation of proteasomal protein catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of proteasomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRP2, ANAPC7, and SLC22A9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of proteasomal protein catabolic process activity versus DRP2 in CCRCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DRP2 →	-0.141	-0.175	.007	.001	3	5
LSCC	ANAPC7 →	-0.548	-0.127	<.001	<.001	3	5
LSCC	SLC22A9 →	-1.030	-0.139	<.001	<.001	3	4
OV	RUNDC1 →	-0.400	-0.121	.004	.007	3	4
LSCC	MIB1 →	-0.425	-0.094	.003	.007	3	4
HNSC	PCYT1B →	-0.897	-0.175	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901800 vs DRP2 — CCRCC

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