Positive regulation of proteasomal protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of proteasomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAYSD1, WAPL, and IER5L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAYSD1 grouped by Positive regulation of proteasomal protein catabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SAYSD1 →	+0.523	+0.128	.001	.003	3	4
LUNG_NSCLC_LUAD	WAPL →	-0.419	-0.076	<.001	.007	2	5
BONE	IER5L →	-1.645	-0.190	.004	.001	3	4
SOFT_TISSUE	RETREG2 →	+0.654	+0.166	.001	.002	3	3
SOFT_TISSUE	PCGF5 →	-1.994	-0.146	.003	.005	3	3
OESOPHAGUS	NCS1 →	-1.154	-0.095	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAYSD1 by Positive regulation of proteasomal protein catabolic process activity — OVARY

Explore this box plot interactively →