Positive regulation of proteasomal protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of proteasomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARD3, SLC12A9, and CLCF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of proteasomal protein catabolic process activity versus PARD3 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PARD3 →	+1.627	+0.237	.003	.005	2	6
BLOOD_Lymphoma	SLC12A9 →	-0.722	-0.169	<.001	<.001	3	5
BONE	CLCF1 →	-2.261	-0.194	.001	<.001	3	5
STOMACH	RAE1 →	-0.988	-0.205	.001	.008	3	4
BONE	SDC4 →	-2.808	-0.219	.005	.002	3	4
URINARY_TRACT	ORC3 →	+0.783	+0.175	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901800 vs PARD3 — UPPER_AERODIGESTIVE_TRACT

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