Positive regulation of signal transduction by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Positive regulation of signal transduction by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFPT1, SAPCD2, and DNAJC3-DT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of signal transduction by p53 class mediator activity versus GFPT1 in LSCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GFPT1 →	-0.547	-0.161	<.001	.001	3	5
CCRCC	SAPCD2 →	-0.325	-0.076	<.001	.004	3	4
HNSC	DNAJC3-DT →	-0.431	-0.102	.005	.007	3	4
HNSC	SYNGR1 →	-0.753	-0.113	.002	.002	3	4
LSCC	NT5C3B →	-0.541	-0.141	.001	.001	3	4
GBM	CDC42BPA →	-0.317	-0.143	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901798 vs GFPT1 — LSCC

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