Positive regulation of signal transduction by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Positive regulation of signal transduction by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBPL1, NUP88, and PARD6B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of signal transduction by p53 class mediator activity versus TBPL1 in BREAST (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TBPL1 →	+0.921	+0.157	<.001	<.001	3	5
LARGE_INTESTINE	NUP88 →	+0.549	+0.183	.007	.002	3	4
STOMACH	PARD6B →	-1.140	-0.224	.006	<.001	3	4
STOMACH	RGS16 →	+1.983	+0.183	.002	.006	3	4
LARGE_INTESTINE	PSMG1 →	+0.895	+0.216	<.001	<.001	3	4
BREAST	PREX1 →	-3.508	-0.178	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901798 vs TBPL1 — BREAST

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