Negative regulation of signal transduction by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Negative regulation of signal transduction by p53 class mediator pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, ITIH2, and DOCK11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of signal transduction by p53 class mediator activity versus C1R in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1R →	+0.657	+0.040	<.001	<.001	3	6
BRCA	ITIH2 →	+0.545	+0.025	<.001	.007	3	6
OV	DOCK11 →	+0.537	+0.026	<.001	.006	3	6
BRCA	SNX6 →	+0.180	+0.030	.002	.001	3	5
GBM	C1QA →	+0.549	+0.046	<.001	<.001	3	5
BRCA	C8A →	+0.528	+0.025	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901797 vs C1R — OV

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