Negative regulation of signal transduction by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Negative regulation of signal transduction by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN10, PRSS12, and SH2D7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of signal transduction by p53 class mediator activity versus CLDN10 in UCEC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLDN10 →	-1.165	-0.533	.008	.003	3	3
OV	PRSS12 →	-1.420	-0.369	<.001	.002	3	3
CCRCC	SH2D7 →	-0.163	-0.184	.001	.003	3	3
CCRCC	EML4-AS1 →	-0.410	-0.160	.003	.008	3	3
COAD	GOLGA6A →	-0.017	-0.872	.002	<.001	3	3
OV	TRMT112P2 →	-0.217	-0.292	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901797 vs CLDN10 — UCEC

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