Negative regulation of signal transduction by p53 class mediator

Across TCGA cell cohorts, RNA activity of the Negative regulation of signal transduction by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD109, CD163L1, and PXK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of signal transduction by p53 class mediator activity versus CD109 in BREAST (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CD109 →	+1.971	+0.172	.007	.003	3	5
BREAST	CD163L1 →	+2.049	+0.180	<.001	<.001	3	5
URINARY_TRACT	PXK →	+1.311	+0.270	.005	<.001	2	6
SKIN	OSTM1 →	+1.140	+0.131	<.001	.003	3	5
URINARY_TRACT	IFI16 →	+2.066	+0.314	.005	.001	3	5
OVARY	TCN2 →	+2.023	+0.266	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901797 vs CD109 — BREAST

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