Leukotriene D4 biosynthetic process

Across TCGA patient cohorts, RNA activity of the Leukotriene D4 biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL14A1, AOC3, and OLFML1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene D4 biosynthetic process activity versus COL14A1 in BRCA (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL14A1 →	+1.127	+0.111	<.001	<.001	3	8
BRCA	AOC3 →	+0.834	+0.094	<.001	<.001	3	8
BRCA	OLFML1 →	+0.997	+0.111	<.001	<.001	3	8
BRCA	PODN →	+0.645	+0.067	<.001	<.001	3	8
BRCA	RPL12_S38 →	-0.928	-0.094	<.001	.001	3	7
PDAC	SEPTIN2 →	+0.250	+0.079	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901750 vs COL14A1 — BRCA

Explore this scatter interactively →