Leukotriene D4 biosynthetic process

Across TCGA cell cohorts, RNA activity of the Leukotriene D4 biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LHX6, FAM171A2, and RAC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LHX6 grouped by Leukotriene D4 biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LHX6 →	+1.409	+1.019	.001	.005	3	4
PANCREAS	FAM171A2 →	+1.551	+1.790	.009	<.001	3	4
LUNG_NSCLC_LUAD	RAC2 →	-3.410	-0.927	.001	.009	3	4
CNS	ACLY →	+0.550	+0.943	.004	.004	3	4
CNS	REPS2 →	-0.579	-0.866	<.001	<.001	3	4
KIDNEY	IL37 →	-0.189	-0.742	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LHX6 by Leukotriene D4 biosynthetic process activity — STOMACH

Explore this box plot interactively →