Positive regulation of myoblast fusion

Across TCGA cell cohorts, RNA activity of the Positive regulation of myoblast fusion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMSAP3, AARS2, and RABEPK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAMSAP3 grouped by Positive regulation of myoblast fusion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CAMSAP3 →	+1.488	+1.160	.008	.002	3	5
LUNG_SCLC	AARS2 →	+0.763	+1.540	.004	<.001	3	4
LUNG_SCLC	RABEPK →	-0.957	-1.162	<.001	.002	3	4
LUNG_SCLC	SDF4 →	-1.060	-1.184	.007	.005	3	4
OVARY	RIN3 →	-1.328	-0.965	.002	.007	2	5
CNS	VWA8 →	+0.659	+1.294	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAMSAP3 by Positive regulation of myoblast fusion activity — LUNG_SCLC

Explore this box plot interactively →