Regulation of myoblast fusion

Across TCGA patient cohorts, RNA activity of the Regulation of myoblast fusion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RGS19, SKAP2, and WAS, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myoblast fusion activity versus RGS19 in UCEC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RGS19 →	+0.687	+0.072	<.001	.001	3	10
UCEC	SKAP2 →	+0.873	+0.130	<.001	<.001	3	10
GBM	WAS →	+0.769	+0.106	<.001	<.001	3	10
UCEC	ADA2 →	+0.682	+0.125	<.001	<.001	3	10
UCEC	CD4 →	+0.709	+0.069	<.001	.002	3	10
UCEC	CYBB →	+1.059	+0.082	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901739 vs RGS19 — UCEC

Explore this scatter interactively →