Regulation of myoblast fusion

Across TCGA patient cohorts, RNA activity of the Regulation of myoblast fusion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZAP70, GAB3, and CD5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myoblast fusion activity versus ZAP70 in HNSC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZAP70 →	+0.913	+0.241	.001	.003	3	8
LSCC	GAB3 →	+0.422	+0.281	<.001	<.001	3	8
HNSC	CD5 →	+0.946	+0.407	<.001	<.001	3	7
HNSC	CD48 →	+0.947	+0.287	<.001	<.001	3	7
HNSC	CD6 →	+1.010	+0.414	<.001	.001	3	7
HNSC	SCML4 →	+0.648	+0.310	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901739 vs ZAP70 — HNSC

Explore this scatter interactively →