Regulation of myoblast fusion

Across TCGA cell cohorts, RNA activity of the Regulation of myoblast fusion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNGAP1, FOS, and RNMT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYNGAP1 grouped by Regulation of myoblast fusion-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SYNGAP1 →	+1.302	+0.699	.005	.003	3	5
LARGE_INTESTINE	FOS →	-1.478	-0.215	.005	.009	3	4
SKIN	RNMT →	+0.526	+0.308	<.001	<.001	3	4
OESOPHAGUS	BRSK1 →	+2.063	+0.310	.001	.004	3	4
OESOPHAGUS	BRSK2 →	+1.398	+0.300	.001	<.001	3	4
OESOPHAGUS	PRAME →	+2.715	+0.275	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYNGAP1 by Regulation of myoblast fusion activity — BLOOD_Lymphoma

Explore this box plot interactively →