Regulation of myoblast fusion

Across TCGA cell cohorts, RNA activity of the Regulation of myoblast fusion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL19, ACTR2, and TOMM40L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myoblast fusion activity versus MRPL19 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRPL19 →	+0.757	+0.196	.009	.001	3	5
UPPER_AERODIGESTIVE_TRACT	ACTR2 →	+0.953	+0.210	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TOMM40L →	+0.684	+0.172	.006	.008	3	5
BLOOD_Lymphoma	FYCO1 →	+1.448	+0.194	.002	<.001	3	5
BREAST	BIK →	-1.875	-0.200	<.001	.001	3	5
LARGE_INTESTINE	ZMAT3 →	+1.370	+0.223	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901739 vs MRPL19 — UPPER_AERODIGESTIVE_TRACT

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