Positive regulation of platelet aggregation

Across TCGA cell cohorts, RNA activity of the Positive regulation of platelet aggregation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMNAT2, PSMC4, and DDX60, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NMNAT2 grouped by Positive regulation of platelet aggregation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NMNAT2 →	+2.373	+0.922	<.001	.002	3	4
STOMACH	PSMC4 →	+0.909	+1.604	.003	.009	3	3
STOMACH	DDX60 →	+2.140	+1.745	.009	.001	3	3
STOMACH	KEL →	-0.621	-1.458	.006	.004	3	3
LUNG_SCLC	SNX16 →	-0.936	-1.001	<.001	.005	3	3
LUNG_SCLC	FHL2 →	+2.761	+1.246	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NMNAT2 by Positive regulation of platelet aggregation activity — OVARY

Explore this box plot interactively →