Positive regulation of platelet aggregation

Across TCGA cell cohorts, RNA activity of the Positive regulation of platelet aggregation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMERB1, BTN1A1, and FCGR3A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMERB1 grouped by Positive regulation of platelet aggregation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BMERB1 →	+0.235	+1.784	.007	.001	3	4
URINARY_TRACT	BTN1A1 →	-0.220	-0.434	.005	.002	3	3
URINARY_TRACT	FCGR3A →	+0.383	+0.487	.001	.002	3	3
OVARY	GTF2H1 →	-0.255	-0.282	<.001	.002	3	3
BREAST	KIF21A →	-0.099	-0.141	.003	.002	3	3
BREAST	HOXD8 →	-0.138	-0.188	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMERB1 by Positive regulation of platelet aggregation activity — BONE

Explore this box plot interactively →