Positive regulation of platelet aggregation

Across TCGA cell cohorts, RNA activity of the Positive regulation of platelet aggregation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRB3, LLGL2, and ALDH3B2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of platelet aggregation activity versus CRB3 in PANCREAS (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CRB3 →	+3.640	+1.310	.001	.004	3	5
PANCREAS	LLGL2 →	+2.078	+1.305	.005	.006	3	4
LUNG_NSCLC_LUAD	ALDH3B2 →	+2.317	+1.032	.003	.001	3	4
LUNG_NSCLC_LUAD	EPN3 →	+3.203	+0.876	<.001	.004	3	4
PANCREAS	ICA1 →	+2.525	+1.310	.002	.004	3	3
PANCREAS	LSR →	+2.823	+1.410	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901731 vs CRB3 — PANCREAS

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