Positive regulation of cell proliferation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell proliferation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCOR, IKBKE, and PRELID2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCOR grouped by Positive regulation of cell proliferation involved in kidney development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BCOR →	-1.052	-1.505	<.001	<.001	3	5
LUNG_SCLC	IKBKE →	+2.204	+1.432	.001	.007	3	4
LUNG_SCLC	PRELID2 →	+2.011	+1.335	.002	.004	3	3
STOMACH	BTG2 →	-2.602	-0.275	<.001	.009	2	4
STOMACH	GPBAR1 →	-0.221	-0.415	<.001	<.001	3	3
LUNG_SCLC	RIPK2 →	+1.295	+1.221	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCOR by Positive regulation of cell proliferation involved in kidney development activity — LUNG_SCLC

Explore this box plot interactively →