Nucleotide transmembrane transport

Across TCGA patient cohorts, RNA activity of the Nucleotide transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MISP_S675, TJP3_S319, and CASKIN2_S878, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide transmembrane transport activity versus MISP_S675 in OV (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MISP_S675 →	-0.797	-0.030	.003	.003	3	5
OV	TJP3_S319 →	-1.231	-0.040	.002	.001	3	4
PDAC	CASKIN2_S878 →	+1.220	+0.048	.009	.002	3	4
LUAD	DEF8_S501 →	+0.426	+0.028	.002	.001	3	4
PDAC	EPB41L2_S627 →	+0.559	+0.026	.005	.005	3	4
CCRCC	CLASRP_S547 →	-0.209	-0.029	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901679 vs MISP_S675 — OV

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