Nucleotide transmembrane transport

Across TCGA patient cohorts, RNA activity of the Nucleotide transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDHP28, NAPSB, and HNRNPDP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleotide transmembrane transport activity versus GAPDHP28 in BRCA (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAPDHP28 →	+0.279	+0.413	<.001	.004	3	4
PDAC	NAPSB →	-0.485	-0.213	.007	<.001	3	4
COAD	HNRNPDP1 →	+0.173	+0.100	.004	.003	3	3
OV	C7 →	-1.901	-0.166	.009	.007	3	3
UCEC	PLCL2 →	-1.059	-0.285	<.001	<.001	3	3
UCEC	CD3D →	-1.221	-0.230	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901679 vs GAPDHP28 — BRCA

Explore this scatter interactively →