Nucleotide transmembrane transport

Across TCGA cell cohorts, RNA activity of the Nucleotide transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT10B, ZNF516, and VANGL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRMT10B grouped by Nucleotide transmembrane transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TRMT10B →	+0.558	+0.865	<.001	.008	3	4
CNS	ZNF516 →	+1.095	+0.982	<.001	<.001	3	3
CNS	VANGL2 →	+1.671	+0.975	.002	<.001	3	3
CNS	FAM83G →	-1.016	-0.735	.007	.007	2	4
LUNG_SCLC	STMN3 →	+3.369	+0.436	.001	.001	3	3
LUNG_SCLC	SYN1 →	+2.528	+0.562	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRMT10B by Nucleotide transmembrane transport activity — KIDNEY

Explore this box plot interactively →