Iron coordination entity transport

Across TCGA patient cohorts, RNA activity of the Iron coordination entity transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP6, FOXK1, and ARHGAP30_S709, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron coordination entity transport activity versus CASP6 in UCEC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CASP6 →	-0.319	-0.053	<.001	.003	3	4
BRCA	FOXK1 →	-0.215	-0.040	<.001	<.001	3	4
CCRCC	ARHGAP30_S709 →	+0.480	+0.047	<.001	<.001	3	4
BRCA	CACNA2D2 →	+0.697	+0.038	.004	.003	3	4
GBM	ADGRL2_S1409 →	-0.541	-0.034	.001	.005	3	4
PDAC	MYSM1_S110 →	-0.567	-0.051	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901678 vs CASP6 — UCEC

Explore this scatter interactively →