Iron coordination entity transport

Across TCGA patient cohorts, RNA activity of the Iron coordination entity transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF626, NAMPT, and KCNK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron coordination entity transport activity versus ZNF626 in GBM (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF626 →	-0.499	-0.149	<.001	<.001	3	5
LSCC	NAMPT →	+1.262	+0.202	<.001	<.001	3	4
LSCC	KCNK1 →	+0.826	+0.184	.003	.001	3	4
GBM	PRPH2 →	-0.367	-0.130	<.001	<.001	3	4
GBM	ZNF835 →	-0.422	-0.133	.001	<.001	3	4
GBM	FCHO1 →	-0.510	-0.121	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901678 vs ZNF626 — GBM

Explore this scatter interactively →