Iron coordination entity transport

Across TCGA cell cohorts, RNA activity of the Iron coordination entity transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTAN1, SLC46A1, and STK10, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron coordination entity transport activity versus NTAN1 in LUNG_NSCLC_LUSC (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NTAN1 →	-1.383	-0.151	<.001	<.001	3	13
KIDNEY	SLC46A1 →	+1.177	+0.079	.005	.002	3	11
BONE	STK10 →	-1.804	-0.134	<.001	<.001	3	11
BONE	ETS1 →	-4.063	-0.104	<.001	<.001	3	11
BONE	ILK →	-1.211	-0.098	<.001	<.001	3	11
LUNG_NSCLC_LUSC	CYB5R3 →	-1.257	-0.146	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901678 vs NTAN1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →